Fosaprepitant dimeglumine
Emend, Focinvez, Fosaprepitant Dimeglumine, Ivemend (fosaprepitant dimeglumine) is a small molecule pharmaceutical. Fosaprepitant dimeglumine was first approved as Ivemend on 2008-01-11. It has been approved in Europe to treat neoplasms and vomiting.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Emend, Focinvez, Fosaprepitant dimeglumine (discontinued: Emend, Fosaprepitant dimeglumine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fosaprepitant dimeglumine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EMEND | Merck & Co | N-022023 RX | 2010-11-12 | 1 products, RLD, RS |
| FOCINVEZ | SteriScience | N-216686 RX | 2023-08-22 | 1 products, RLD, RS |
| FOSAPREPITANT DIMEGLUMINE | Teva | N-210064 RX | 2019-09-05 | 1 products |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aponvie | New Drug Application | 2024-03-13 |
| aprepitant | ANDA | 2024-09-09 |
| aprepitant aprepitant | ANDA | 2024-10-02 |
| cinvanti | New Drug Application | 2024-03-13 |
| emend | New Drug Application | 2024-07-05 |
| focinvez | New Drug Application | 2024-11-29 |
| fosaprepitant | ANDA | 2024-12-29 |
| fosaprepitant dimeglumine | ANDA | 2024-08-15 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
FOSAPREPITANT DIMEGLUMINE, EMEND, MERCK AND CO INC | |||
| 2025-05-02 | D-186 | ||
Patent Expiration
No data
HCPCS
No data
Clinical
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Drug
General
| Drug common name | Fosaprepitant dimeglumine |
| INN | aprepitant |
| Description | Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is an antiemetic medication, administered intravenously. It is a prodrug of aprepitant.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; tachykinin (neurokinin) receptor antagonists: NK1 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@H]1OCCN(Cc2nn(P(=O)(O)O)c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 172673-20-0 |
| RxCUI | 1731071 |
| ChEMBL ID | CHEMBL1201782 |
| ChEBI ID | 64311 |
| PubChem CID | 219090 |
| DrugBank | DB06717 |
| UNII ID | 6L8OF9XRDC (ChemIDplus, GSRS) |
Target
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Emend – Merck & Co
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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