Emend, Ivemend(fosaprepitant dimeglumine)
Emend, Focinvez, Ivemend (fosaprepitant dimeglumine) is a small molecule pharmaceutical. Fosaprepitant dimeglumine was first approved as Ivemend on 2008-01-11. It has been approved in Europe to treat neoplasms and vomiting.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Emend (generic drugs available since 2016-06-09)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fosaprepitant dimeglumine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EMEND | Merck Sharp & Dohme | N-022023 RX | 2010-11-12 | 1 products, RLD, RS |
| FOSAPREPITANT DIMEGLUMINE | Teva | N-210064 RX | 2019-09-05 | 1 products |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aponvie | New Drug Application | 2023-09-14 |
| aprepitant | ANDA | 2020-12-24 |
| aprepitant aprepitant | ANDA | 2022-07-08 |
| cinvanti | New Drug Application | 2023-09-14 |
| emend | New Drug Application | 2023-12-01 |
| focinvez | New Drug Application | 2023-08-31 |
| fosaprepitant | ANDA | 2023-07-25 |
| fosaprepitant dimeglumine | ANDA | 2023-12-04 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
FOSAPREPITANT DIMEGLUMINE, EMEND, MERCK AND CO INC | |||
| 2025-05-02 | D-186 | ||
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
219 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | 8 | 25 | 28 | 10 | 15 | 85 |
| Nausea | D009325 | HP_0002018 | R11.0 | 2 | 13 | 6 | 6 | 7 | 34 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | 2 | 2 | 3 | 14 | 9 | 29 |
| Neoplasms | D009369 | — | C80 | 2 | 2 | 4 | 2 | 4 | 13 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | 4 | 2 | 2 | 11 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | 2 | 4 | 7 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | 1 | 4 | 6 |
| Leukemia | D007938 | — | C95 | — | — | — | 2 | 3 | 5 |
| Pruritus | D011537 | HP_0000989 | L29 | — | 2 | — | 1 | 1 | 4 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | 1 | — | 4 |
Show 6 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 9 | — | — | 9 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | — | 1 | — | 3 | 4 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 2 | 1 | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | 1 | — | 1 | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | 1 | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | 1 | — | 1 | 3 |
| Nasopharyngeal neoplasms | D009303 | — | — | 1 | — | 1 | — | — | 2 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | — | 1 | — | 1 | 2 |
| Female genital neoplasms | D005833 | — | — | — | — | 1 | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | — | — | 1 | — | — | 1 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | 3 | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 2 | — | — | 1 | 4 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 3 | — | — | — | 3 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | 2 | — | — | — | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | 1 | 3 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | — | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | 1 | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | 1 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
Show 13 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | — | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 2 | — | — | — | — | 2 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 1 | — | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | — | — | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | 1 | — | — | — | — | 1 |
| Heroin dependence | D006556 | EFO_0004240 | — | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasma cell neoplasms | D054219 | — | — | — | — | — | — | 3 | 3 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 2 | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | — | — | — | 2 | 2 |
| Trophoblastic neoplasms | D014328 | — | — | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
| Genetic polymorphism | D011110 | — | — | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | HP_0001907 | — | — | — | — | — | 1 | 1 |
| Brenner tumor | D001948 | — | — | — | — | — | — | 1 | 1 |
| Endometrioid carcinoma | D018269 | — | — | — | — | — | — | 1 | 1 |
| Fallopian tube neoplasms | D005185 | — | — | — | — | — | — | 1 | 1 |
Show 10 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fosaprepitant dimeglumine |
| INN | aprepitant |
| Description | Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is an antiemetic medication, administered intravenously. It is a prodrug of aprepitant.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; tachykinin (neurokinin) receptor antagonists: NK1 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@H]1OCCN(Cc2nn(P(=O)(O)O)c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 172673-20-0 |
| RxCUI | 1731071 |
| ChEMBL ID | CHEMBL1201782 |
| ChEBI ID | 64311 |
| PubChem CID | 219090 |
| DrugBank | DB06717 |
| UNII ID | 6L8OF9XRDC (ChemIDplus, GSRS) |
Target
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Emend – Merck Sharp & Dohme
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Safety
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Adverse Events
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4,901 adverse events reported
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